#Neuroblastology! Stage 1 of the project gets underway

 

Guest post by Hannah Davies

A bit about the project…

We are living longer – which is great – however this also increases the incidence of diseases associated with aging. One such condition is Alzheimer’s disease. It is estimated that the cost of dementia to the UK economy is expected to be £59.4 billion by 2050. As such there is a drive to improve diagnosis and generate therapeutic agents that will tackle this devastating disease.

This project (supported by a Biochemical society outreach grant) will raise awareness of the societal implications of an ageing population and dementia alongside demonstration and explanation of some of the types of research that is currently ongoing to increase our understanding of the processes of ageing. A key area of research into understanding the ageing brain is development of in vitro model systems to provide an environment to test new diagnostic and therapeutic agents prior to clinical trials. The emphasis of this project is to give students an understanding of the important role that these cell systems can play in understanding the ageing brain.

This project will have two stages. The first stage will involve collaboration with John Dyer at Liverpool life sciences UTC to develop methodology and teaching materials around cell culture models in the context of the ageing brain. The second stage of the project will be to deliver the workshops/plenaries/practical sessions on the ageing brain to other local schools in the area.

Liverpool life sciences UTC is a specialist school for life sciences and has many students aspiring to work in health and science disciplines. Students are assigned to a selected ‘pathways’ that enables them to tailor their school activities to their future aspirations. One aspect of this is the innovation factory where students can design and test research questions. Currently, they are still developing their labs to accommodate the experiments dreamt up by the students using old instrumentation donated from industry and academia. At present, they have equipment suitable for cell culture (CO2 incubators and laminar flow hoods) but they do not have the expertise or reagents to enable experiments with live cells despite interest from many of their students.

Where we are up to…

On Monday 18th January 2016 after several months of discussions and preparation we took proliferating SHSY-5Y (a neuronal cell-line) cells into UTC. Armed with protocols, risk assessments and lab coats we taught some keen and able representatives from years 11, 12 and 13 how to care for the cells in our absence. The students will culture the cells until they have sufficient for their ambitious experiments. With so many students from several years interested they will need to passage the cells several times to get the volume/number required. Just before February half term they will harvest the cells and perform their experiments.  The students were excellent and I have every faith they will do a great job! Wish them luck!!

Look out for updates (#Neuroblastology) to see how they get on and what exciting experiments they have planned…

 

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