Dementia Public Engagement Day

On Wednesday 23rd May, scientists from Team Madine and Team Turnbull went on a mission to educate the public about dementia research as part of dementia awareness week, at the Alzheimer’s Research UK North West public engagement event hosted at the Institute for Dementia (University of Salford). The event was a hive of activity and a cornucopia of fun! Through the media of Lego®, giant KerPlunk!, cells and real brains members of the public were introduced to all things dementia, including how diet can affect your dementia risk, the development of novel inhibitors of dementia-associated proteins and the links between dementia and other diseases.

Kiani Jeacock, James Torpey (Madine group) and Scott Guimond (Turnbull group) showcased the fantastic research happening at the University of Liverpool through informative posters and a ‘Draw for Dementia’ activity. People were invited to draw the first thing that came to mind when they heard the word “dementia”, which resulted in some really interesting and thought-provoking work!

On the day, they also met people who had dementia themselves or who had friends or family with dementia. This was an educational experience for the scientists too, as it highlighted the translational aspect of their work and emphasised the importance of research into these poorly-understood conditions.

Overall it was a well-organised and enlightening day, and events like these are fantastic for both researchers and the general public alike.

Thanks to ARUK and the Institute for Dementia for hosting!

 

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Meet the Scientists

On Saturday 17th March IIB led the Meet the Scientists Event at the World Museum. Activities included stands led by the CCI and Madine group from IIB along with other stands from Life Sciences, ITM and IGH.

The CCI had a large team, and all worked together brilliantly on the Seeing is Believing stand! The team included:

Violaine See (CCI staff): Preparation of samples for imaging, and assistance at the event.

Dave Mason (CCI staff): Preparation of samples, imaging of samples, produced posters for the event, and assistance at the event.

Marco Marcello (CCI staff): Organisation of virtual reality tours of microscopy images, with Virtual Arcade

Daimark Bennett (CCI staff): Preparation of samples for imaging, and assistance at the event.

Raphael Levy (CCI staff): Preparation of samples for imaging, and assistance at the event.

Anne Herrmann (Postdoctoral researcher): Imaging of samples, preparation of printed materials for the drawing microscopy station.

Sophie Cowman (PhD student): Filmed and produced a tour of the CCI facility, which was on display during the event.

Rebecca Kelly (PhD student): Preparation of CCI postcards, set up and take down of stand, and assistance at event especially for the match the picture quiz.

Claire Kelly (PhD student): Set up and take down of stand, and assistance at event especially for the virtual reality microscopy tour.

Hammed Badmos (PhD student): Preparation of samples, and assistance at event especially for the microscope demonstrations.

Jen Francis (PhD student): Assistance at event especially for the microscope demonstrations.

Sumaira Ashraf (Postdoctoral researcher): Set up and take down of stand, and assistance at event especially for the microscope demonstrations.

Jen Adcott (CCI Staff): Organisation of the Seeing is Believing stand and co-ordinator of activities, imaging of samples, designed and produced the match the picture quiz and microscopy stickers, and assistance at the event.

Feedback from the CCI stand, seeing is believing:

Violaine See – “It was great, and the activities were all very popular. What I really liked about our exhibit is that it was real science. Well done Jen A for leading this, the result was absolutely awesome. Well done Jen F, Hammed, and Sumaira for guiding the kids with the microscopes with so much patience and enthusiasm. Dave has been an absolute star with the colouring sheets and at explaining what we do with microscopes. Rebecca and Claire have been fantastic with the quiz and virtual reality. An amazing team effort. I feel very fortunate to have you all around, you are amazing.”

Daimark Bennett – “Fantastic effort by everyone and great activities – it was great to see how busy it was even later on. The VR clearly went down a storm and everything from the stickers to the CCI movie looked really professional and well put together. It really is hard to convey the science when it’s so chaotic but I think the exhibit was pitched at the right level. In any case, my daughter, who is not easy to impress, gave the thumbs up 🙂 Well done everyone!”

Jen Adcott – “It’s great to work with such a fantastic team of people! The day was busy, and the CCI stand seeing is believing was hugely popular with many repeat visitors. I am looking forward to meeting more future scientists at the next events.”

The Madine group ran 2 activities ‘How does the heart work?’ and return of the popular ‘A lego treasure hunt for new medicines!’ with the help of PhD students James Torpey and Nathan Cumberbatch, MRes student Kiani Jeacock and undergraduate volunteers.  Visitors enjoyed learning how blood is transported around the body by watching blood cells flow around the giant circulatory system (borrowed from IACD created with a Wellcome Trust Public Engagement award, granted to Dr Valentina Barrera). Children of all ages were keen to take part in the Lego treasure hunt around the museum to find the correct drug that fit the Lego protein molecule, and be rewarded with a Lego Scientist to take home. Thanks to members of the group for their help and enthusiasm when describing the drug development process through the use of Lego.

Range High School Students annual visit to NMR Centre

On Friday 9th March 15 chemistry A-Level students from Range High School visited the Institute for a workshop in the NMR Centre for Structural Biology organised by Dr Jill Madine and Dr Marie Phelan. This visit has been an annual event for the past several years which the students look forward to in order to gain enhanced understanding of NMR to help with their A-level courses and also gain an insight into what goes on in an academic research environment.  The students were given lectures on the basic applications of mass spectrometry and NMR from Stephen Moss (School of Physical Sciences) and Dr Marie Phelan. This was the followed by practical workshops where the students carried out chromatography and learnt to prepare and run NMR samples along with how to interpret the data.  Prior to their visit, as part of a school practical, they have made salicylic acid – a precursor for aspirin. We obtained these samples and collected NMR spectra of their products ready for analysis on the day.  This enabled them to establish how successful their synthesis had been and compare their results across the class, with previous years’ students (and to the teacher!). This final part of the day is always the most exciting for the students where there is no hiding that they actually dropped their sample and scraped it off the desk!

PhD student James Torpey along with internship students Daniel Thomas and Raven Chandramohan  helped with the day providing practical and theoretical advice.

Dementia Awareness Week Public Engagement Event

Dementia awareness week (15th – 20th May) has all been wrapped up, and in light of the event Dr Jill Madine and her amyloid group (Kieran Hand, Dr Hannah Davies and James Torpey), Prof Jerry Turnbull and Dr Scott Guimond (Institute of Integrative Biology), and Prof Alan Morgan (Institute of Translational Medicine) participated in the Alzheimer’s Research UK North West public engagement event hosted by the University of Salford on Wednesday 17th May 2017. To celebrate the grand opening of the Universities new Dementia hub, scientific researchers from the University of Manchester, MMU, University of Liverpool, University of Salford and Liverpool John Moore’s engaged in an academic event in the morning showcasing what dementia research is taking place at each institution, followed by an afternoon demonstrating their on going efforts to tackle this life changing disease… to the public!  A breadth of “hands on” activities were available for all ages, and we also invited Liverpool Life Sciences UTC to get stuck in and showcase their ongoing collaborative projects! Activities ranged from how worms are really changing the way in which we can study dementia (with some brilliant videos) (Morgan group), how a ‘spoonful of sugar’ could help treat dementia (Turnbull group) and all the way to what dementia means to you (Madine group). In this activity, the Madine amyloid group asked individuals or groups if they could write or draw their feelings on dementia, have their photo taken with their work, where the public were delighted with the idea that it’s going to be made into a collage for others that were unable to attend the event to see. There were some truly incredible thoughts on the subject from individuals who had been directly impacted by dementia, and as a group we were incredibly humbled by the positive responses to our ongoing efforts in Alzheimer’s, Parkinson’s and associated disorders. See you next year!

Postcard from Vienna, Alzheimer’s disease and Parkinson’s disease (ADPD) conference – 2017

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This was a huge display within the conference venue – amazing photography!

Last week three members of IIB, Dr Hannah Davies, James Torpey and Prof. Jerry Turnbull went to Vienna to find out about the latest research and technological advances in the field of neurodegeneration and dementia at ADPD 2017. This five day conference saw over 3000 clinicians, researchers industry specialists from around the globe discuss recent advances in the field, including reports on the latest drug trails, new avenues for treatment and patient perspectives. This busy meeting gave us the opportunity to catch up with colleagues from around the world, and share the exciting research we are doing here at Liverpool with a huge audience.

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The conference venue and an action shot of James presenting his findings at one of the poster sessions

During our stay in Vienna we were treated to welcome reception at Vienna’s beautiful City Hall, we ate traditional Austrian dishes, talked science and enjoyed an impromptu opera performance from one of our colleagues!

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Welcome reception in the impressive Vienna city hall

We came away from the conference, tired but full of new ideas and renewed enthusiasm for our projects.

Range High School Students annual visit to NMR Centre

On Wednesday 18th January chemistry A-Level students from Range High School visited the Institute for a workshop in the NMR Centre for Structural Biology organised by Dr Jill Madine. This visit has become an annual event which the students enjoy and say enhance their understanding of how NMR can be applied in a research environment.  The students learnt about the advantages and disadvantages of mass spec and NMR from Dr Mark Wilkinson and Dr Marie Phelan, carried out chromatography and learnt to prepare  and run NMR samples and how to interpret the data.  Prior to their visit, as part of a school practical, they have made salicylic acid – a precursor for aspirin. We obtained these samples and collected NMR spectra of their products ready for analysis on the day.  This enabled them to establish how successful their synthesis had been and compare their results across the class, with previous years’ students (and to the teacher!). 

A range of University of Liverpool postgraduate students and postdocs helped with the day providing practical and theoretical advice, including Dr Hannah Davies, Rudi Grossman, James Torpey and Kieran Hand (pictured above).

Marvellous Medicine at Meet the Scientists

Guest post by Rorie Hather

Meet the Scientists” is a regular programme of events that takes place at the World Museum Liverpool and organised by the University of Liverpool’s Faculty of Health and Life Science with the support of the Wellcome Trust.  On Saturday 26th November the event drew again a large turnout of visitors. The overall theme was “Marvellous Medicines”. It focused on where our medicines come from, the different methods we use to treat diseases as well as the future of modern medicine. The day involved research teams from across the University of Liverpool lending their time and resources to run eight interactive stalls aimed at ensuring a fun and informative day for the whole family, regardless of age.

Two stalls out of the eight stemmed from different research teams within the Institute of Integrative Biology.  Dr. Raphaël Lévy’s team together with colleagues from the Institute of Translational Medicine (Toni Plagge and his student Joe Robertson) had a stall on “stem cells and nanoparticles”. Dr. Madine’s amyloid group utilised Lego pieces to show how proteins interact with one another and how this impacts their research into neurodegenerative and cardiovascular amyloid diseases.

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Golden? The beautiful colours of gold nanospheres and nanorods in water. The infrared absorption of some of these nanomaterials can be used to image cells in tissues.

The stem cells and nanoparticles stall attempted to translate the ongoing UK Regenerative Medicine Platform work into interactive games to help understand just how small nanoparticles are, as well as showing where stem cells are found within our body and the possible contributions they may be able to have to modern medical science.

A “pin the organ on the human” game was also run, involving visitors placing organ cutouts onto an outline of a human they drew onto a whiteboard, hopefully in the correct place. This game helped to show where exactly our organs are located, and how they each hold stem cells vital to our ongoing health and regeneration. (The freely available resources developed by Eurostemcells are available here if you wish to try this yourself.)  In total, 7 people help run the activity throughout the day: Sumaira Ashraf, Joe Robertson, Elizabeth Grimes, Joan Comenge, Rorie Hather, Angela Midgley and Raphaël Lévy

Dr. Madine’s group used a highly popular tactic among many of the younger visitors. Their game, invented by Kieran Hand and James Torpey, involved using Lego pieces to demonstrate how small molecules can dock to target proteins implicated in the diseases they research. Children were sent on a scavenger hunt around the different stalls to find the hidden complementary shape of Lego that would fit to their existing protein. On their stall, PhD student Kieran Hand said one of their aims was to raise awareness of light chain amyloidosis – a disease that is often left out of the limelight, yet impacts a similar number of people as motor neurone disease. The prizes that had been assembled to give to children who were successful in the drug discovery hunt ran out by 2 pm, showing just how busy the event was. Hammed Badmos also helped on the stall during the day.

The Meet the Scientists series continues into the new year, with the next event, “Brainiacs”, taking place on the 21st January 2017. It will explore the complexities, faults and cures that surround the human brain.

Find out more about future events here.