Dementia Awareness Week Public Engagement Event

Dementia awareness week (15th – 20th May) has all been wrapped up, and in light of the event Dr Jill Madine and her amyloid group (Kieran Hand, Dr Hannah Davies and James Torpey), Prof Jerry Turnbull and Dr Scott Guimond (Institute of Integrative Biology), and Prof Alan Morgan (Institute of Translational Medicine) participated in the Alzheimer’s Research UK North West public engagement event hosted by the University of Salford on Wednesday 17th May 2017. To celebrate the grand opening of the Universities new Dementia hub, scientific researchers from the University of Manchester, MMU, University of Liverpool, University of Salford and Liverpool John Moore’s engaged in an academic event in the morning showcasing what dementia research is taking place at each institution, followed by an afternoon demonstrating their on going efforts to tackle this life changing disease… to the public!  A breadth of “hands on” activities were available for all ages, and we also invited Liverpool Life Sciences UTC to get stuck in and showcase their ongoing collaborative projects! Activities ranged from how worms are really changing the way in which we can study dementia (with some brilliant videos) (Morgan group), how a ‘spoonful of sugar’ could help treat dementia (Turnbull group) and all the way to what dementia means to you (Madine group). In this activity, the Madine amyloid group asked individuals or groups if they could write or draw their feelings on dementia, have their photo taken with their work, where the public were delighted with the idea that it’s going to be made into a collage for others that were unable to attend the event to see. There were some truly incredible thoughts on the subject from individuals who had been directly impacted by dementia, and as a group we were incredibly humbled by the positive responses to our ongoing efforts in Alzheimer’s, Parkinson’s and associated disorders. See you next year!

Postcard from Vienna, Alzheimer’s disease and Parkinson’s disease (ADPD) conference – 2017

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This was a huge display within the conference venue – amazing photography!

Last week three members of IIB, Dr Hannah Davies, James Torpey and Prof. Jerry Turnbull went to Vienna to find out about the latest research and technological advances in the field of neurodegeneration and dementia at ADPD 2017. This five day conference saw over 3000 clinicians, researchers industry specialists from around the globe discuss recent advances in the field, including reports on the latest drug trails, new avenues for treatment and patient perspectives. This busy meeting gave us the opportunity to catch up with colleagues from around the world, and share the exciting research we are doing here at Liverpool with a huge audience.

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The conference venue and an action shot of James presenting his findings at one of the poster sessions

During our stay in Vienna we were treated to welcome reception at Vienna’s beautiful City Hall, we ate traditional Austrian dishes, talked science and enjoyed an impromptu opera performance from one of our colleagues!

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Welcome reception in the impressive Vienna city hall

We came away from the conference, tired but full of new ideas and renewed enthusiasm for our projects.

Range High School Students annual visit to NMR Centre

On Wednesday 18th January chemistry A-Level students from Range High School visited the Institute for a workshop in the NMR Centre for Structural Biology organised by Dr Jill Madine. This visit has become an annual event which the students enjoy and say enhance their understanding of how NMR can be applied in a research environment.  The students learnt about the advantages and disadvantages of mass spec and NMR from Dr Mark Wilkinson and Dr Marie Phelan, carried out chromatography and learnt to prepare  and run NMR samples and how to interpret the data.  Prior to their visit, as part of a school practical, they have made salicylic acid – a precursor for aspirin. We obtained these samples and collected NMR spectra of their products ready for analysis on the day.  This enabled them to establish how successful their synthesis had been and compare their results across the class, with previous years’ students (and to the teacher!). 

A range of University of Liverpool postgraduate students and postdocs helped with the day providing practical and theoretical advice, including Dr Hannah Davies, Rudi Grossman, James Torpey and Kieran Hand (pictured above).

Marvellous Medicine at Meet the Scientists

Guest post by Rorie Hather

Meet the Scientists” is a regular programme of events that takes place at the World Museum Liverpool and organised by the University of Liverpool’s Faculty of Health and Life Science with the support of the Wellcome Trust.  On Saturday 26th November the event drew again a large turnout of visitors. The overall theme was “Marvellous Medicines”. It focused on where our medicines come from, the different methods we use to treat diseases as well as the future of modern medicine. The day involved research teams from across the University of Liverpool lending their time and resources to run eight interactive stalls aimed at ensuring a fun and informative day for the whole family, regardless of age.

Two stalls out of the eight stemmed from different research teams within the Institute of Integrative Biology.  Dr. Raphaël Lévy’s team together with colleagues from the Institute of Translational Medicine (Toni Plagge and his student Joe Robertson) had a stall on “stem cells and nanoparticles”. Dr. Madine’s amyloid group utilised Lego pieces to show how proteins interact with one another and how this impacts their research into neurodegenerative and cardiovascular amyloid diseases.

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Golden? The beautiful colours of gold nanospheres and nanorods in water. The infrared absorption of some of these nanomaterials can be used to image cells in tissues.

The stem cells and nanoparticles stall attempted to translate the ongoing UK Regenerative Medicine Platform work into interactive games to help understand just how small nanoparticles are, as well as showing where stem cells are found within our body and the possible contributions they may be able to have to modern medical science.

A “pin the organ on the human” game was also run, involving visitors placing organ cutouts onto an outline of a human they drew onto a whiteboard, hopefully in the correct place. This game helped to show where exactly our organs are located, and how they each hold stem cells vital to our ongoing health and regeneration. (The freely available resources developed by Eurostemcells are available here if you wish to try this yourself.)  In total, 7 people help run the activity throughout the day: Sumaira Ashraf, Joe Robertson, Elizabeth Grimes, Joan Comenge, Rorie Hather, Angela Midgley and Raphaël Lévy

Dr. Madine’s group used a highly popular tactic among many of the younger visitors. Their game, invented by Kieran Hand and James Torpey, involved using Lego pieces to demonstrate how small molecules can dock to target proteins implicated in the diseases they research. Children were sent on a scavenger hunt around the different stalls to find the hidden complementary shape of Lego that would fit to their existing protein. On their stall, PhD student Kieran Hand said one of their aims was to raise awareness of light chain amyloidosis – a disease that is often left out of the limelight, yet impacts a similar number of people as motor neurone disease. The prizes that had been assembled to give to children who were successful in the drug discovery hunt ran out by 2 pm, showing just how busy the event was. Hammed Badmos also helped on the stall during the day.

The Meet the Scientists series continues into the new year, with the next event, “Brainiacs”, taking place on the 21st January 2017. It will explore the complexities, faults and cures that surround the human brain.

Find out more about future events here.